[Efficacy and safety of TAM-sparing antiretroviral regimens in na?ve HIV-positive patients.] Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive [Infez Med] Journal article | | Title | [Efficacy and safety of TAM-sparing antiretroviral regimens in na?ve HIV-positive patients.] | | Author(s) | Gottardi M, Lanzafame M, Lattuada E, Soldani F, Boccafoglio F, Concia E | | Institution | Unita Operativa di Malattie Infettive, Ospedale Policlinico G.B. Rossi - Borgo Roma, Verona, Italy. | | Source | Infez Med 2009 Sep 1; 17(3):151-158. | | Abstract | To assess the potency, efficacy and toxicity of abacavir/lamivudine (ABC/3TC) versus tenfovir/emcitrabine (TDF/FTC) with efavirenz (EFV) in naive patients with HIV infection a prospective observational study was carried out to evaluate immunovirological parameters every three months and metabolic parameters every six months. In all, 21 patients were enrolled (10 on ABC/3TC and 11 on TDF/FTC). Fisher's test revealed no statistically significant difference between the two arms in terms of immunological recovery and control of viral replication. For metabolic parameters at week 48 no statistically significant differences were noted between the two arms. The two ABC/3TC and TDF/FTC backbones showed the same potency; ABC had a more negative impact on metabolic parameters without statistical power. | | Language | ITA | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19838086 |
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